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CO2, brainstem chemoreceptors and breathing

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Notably, a single administration of semaglutide significantly inhibited the expression of cocaine-induced CPP in animals (Figure 6A), but had no significant effect on the extinction (weakening of an established place preference through repeated unrewarded context exposure) and reinstatement (the re-emergence of that place preference after the extinction and is triggered by a precipitating factor for relapse) of CPP (Figures 6B, 6C)

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