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A heart rate increase of 5 to 10 BPM without symptoms is expected and generally acceptable

In addition, use of corticosteroid therapy and female sex are found predisposing factors for increased risk of MTX intolerance

For standard curves, CAM-S-CAM-TPP and S(CAM-TPP) 2 , were prepared in 20% ACN, 0.1% FA at final concentrations of 0.001 M25 M supplemented with 50 nM of deuterated internal standards

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