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Though the vast majority of NHLs are considered EBV-negative, the latest classification systems recognize several rare EBV-related subtypes, including EBV-positive diffuse large B-cell lymphoma, plasmablastic lymphoma, extranodal NK/T-cell lymphoma (nasal type), primary effusion lymphoma, and some Burkitt lymphomas [7, 8]

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In conclusion, while clinical translation is constrained by delivery, toxicity, and pharmacokinetic hurdles, ferritin-targeted approaches offer a novel and mechanistically rational avenue for treating aggressive brain cancers, warranting further preclinical optimization and early-phase clinical investigation

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