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Maximal reductions of at least 20% were seen in 26% of tirzepatide-treated patients, versus 12% of semaglutide-treated patients
18 Currently, efficacy and the safety of two doses (800 mg and 1,200 mg) of lanifibranor per day for 24 weeks is being evaluated in a phase II study versus placebo in adult NASH patients with moderate to severe necroinflammation without cirrhosis (NCT03008070)
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Weight loss of this magnitude 1521% of body weight includes loss of lean tissue alongside fat
PMID: 36354040
Each receptor limb contributes a distinct downstream effect in preclinical models, and their concurrent activation is hypothesised to produce additive or synergistic metabolic signalling
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