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Nuclear plasma of the membrane undergo oxidation damage, whereas the phospholipid molecules modified by oxygen accumulate in the lipid layer, leading to changes in the structure and violate lipid-lipid and protein-lipid interactions in membranes of the lens fibers

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In non-enzymatic processes, the H 2 O 2 combines with Fe 2+ (e.g., ferritin protein) or Cu 2+ (e.g., ceruplasmin protein) ions in the Fenton reaction, where it accepts an electron from metal ions to form highly reactive (t 1/2 = 10 9 s) HO radical and HO + ion and thus are highly reactivity in the mitochondrial matrix [16]

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Trends Endocrinol Metab 20, 436443, 10.1016/j.tem.2009.05.008 (2009)