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These cascades are context dependent and can be protective in the UV response, although chronic hyperactivation can be oncogenic

GPX4, a selenocysteine-containing enzyme, utilizes GSH to reduce toxic phospholipid hydroperoxides (PL-OOHs) to non-toxic phospholipid alcohols (PL-OHs), thereby disrupting lipid peroxidation chain reactions and preventing oxidative cell injury (Pontel et al., 2022)

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis