Presynaptically, Y2R acts as an autoreceptor on NPY terminals and inhibits the release of endogenous NPY when activated (Chen et al., 1999), thus inhibition of Y2R would result in similar behavioral effects as Y1R-stimulation
I have also been wondering if we should be encouraging those patients to get started on one of the new GLP-1 agonists which are injectable medications that mimic the effects of glucagon-like peptide-1 (GLP-1), a gut hormone that stimulates the release of insulin
Some people use it short-term to reset their metabolism and appetite while they build better habits
You need your semaglutide vial, a U-100 insulin syringe (typically 0.3 mL or 0.5 mL for semaglutide doses), alcohol swabs, and a sharps container
Depending on your health goals, one or the other may be better suited to your individual needs
Other Ingredients: Vegetarian Capsule, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose