They're generally well-tolerated, with Ipamorelin's selectivity a key advantage, but they're research/compounded peptides without complete long-term human data which is why they should be used only under medical supervision, not self-sourced online
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There are now some clinical data demonstrating that CR prolongs life expectancy in individuals by reducing the risk of aging-related diseases, but may adversely affect certain groups, and optimal intake and duration of long-term CR, receptor sensitivity, and degree of activation of post-receptor pathways remain to be determined in further studies
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Maintenance doses required to sustain results
(PubMed) Schillace RV, Pisenti N, Pattamanuch N, et al