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doi:10.1074/jbc.275.5.3693

However, increased activity may expose underlying spinal issues that were previously unnoticed, especially if someone already has: disc bulges herniated discs degenerative disc disease Not all back pain is disc related, but certain symptoms may suggest nerve pressure or disc involvement

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A 2026 study published in The Lancet found a similar pattern with tirzepatide in a similar cohort of postmenopausal women