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Growth hormones anabolic effects protect muscle tissue even during caloric restriction

Biological effects can persist 72 h owing to a prolonged half-life and sustained receptor occupancy

5 Although the natriuretic peptide system normally counterbalances these effects through vasodilation and natriuresis, its function is blunted in HF due to enhanced clearance by neprilysin, thereby limiting its protective impact

Y., Burneskis, J

This indicates the need for close monitoring when GLP-1 RAs and a dual GLP-1/GIP RA are co-administered, especially when starting treatment or increasing the dose

Some treatment plans start with a repletion phase and then move to maintenance dosing