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Abstract In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes

The peptides ability to produce metabolic effects with such rapid plasma clearance (3-minute half-life) while maintaining prolonged biological activity represents a significant knowledge gap requiring further investigation

however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing

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