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Some sleep medications interact with GLP-1 therapy or may mask underlying causes of insomnia that respond to dose adjustments

Body composition in DIO mice with/without NNMT inhibition showing reduced WAT mass with preserved lean mass relative to diet-matched controls [1,3,4]

Watch for increasing fatigue, cold intolerance, constipation beyond what tirzepatide typically causes, dry skin, hair thinning, depression, or unexplained weight gain despite following your diet protocol

doi: 10.1016/j.avsg.2020.10.022 64 ArmstrongDGBoultonAJMBusSA

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Rapid weight loss and metabolic changes influence hormone levels, which can cause irregular periods, heavier or lighter flow, or changes in cycle timing