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257 , L163L173 (1989)
No entanto, as vrias substncias a administrar subcutaneamente diferem nas suas propriedades farmacocinticas, especialmente a meia-vida: os representantes de aco curta (exenatide, lixisenatide) tm uma meia-vida de cerca de 2-4 horas, de aco longa de 13 horas (liraglutido) at 7-14 dias (dulaglutido, exenatide ER, semaglutido), o que permite uma doseamento uma vez por semana para estas ltimas substncias
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