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The VEGFR2-Akt-eNOS angiogenic cascade increases blood vessel formation by 129-152% in preclinical studies
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Glial cells, particularly microglia, are key contributors to neuroinflammation, with microglial activation leading to the production of proinflammatory cytokines like NO, IL-1, and TNF- 42
Gaschler MM, Andia AA, Liu HR, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV
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