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Who Is Generally Excluded FDA labels list contraindications and precautions that typically rule out or require caution with GLP-1 therapy: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to the drug History of pancreatitis (caution, not absolute contraindication) Active gallbladder disease (caution) Severe gastroparesis or other significant GI motility disorders Pregnancy or planning pregnancy (discontinuation typically recommended) Type 1 diabetes (not studied for this indication) Additionally, patients with severe kidney or liver disease, those on certain medications that affect insulin or GI motility, and those with eating disorders should have careful evaluation

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Clinical Development Program of Lixisenatide Phase II Dose-Finding Study The doseresponse effect of lixisenatide was evaluated in a large group ( n = 542) of metformin-treated patients with type 2 diabetes using OD or twice-daily (BD) lixisenatide regimens (530 g OD or BD) [10]

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Early recognition and appropriate management of biliary complications can prevent serious outcomes such as acute cholecystitis, biliary obstruction, or pancreatitis

The split-dose tables in this article show the exact breakdown for each scenario