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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia

E 2 -3,4-Q can be converted back to 4-OHE 2 in a single step by quinone reductase, or in two sequential steps catalysed by P450 reductase via the semiquinone intermediate

doi: 10.15403/jgld.2014.1121.253.rc2 44 HuhtaHHelminenOLehenkariPPSaarnioJKarttunenTJKauppilaJHet al

Upton DH, Ung C, George SM, Tsoli M, Kavallaris M, Ziegler DS