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A variety of factors may determine glutathione requirements, including level of exposure to toxins, increased phase I detoxification activity, and overall need for antioxidant support

Among the best-characterized examples is the miR-15a/16-1 cluster, whose inhibition in endothelial cells enhances claudin-5 expression, reduces vascular leakage, and confers resistance to ischemic injury [239, 240]

Allen JW, Mutkus L, Aschner M (2001) Methylmercury-mediated inhibition of 3H-d-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase

Metal-polyphenol-network coated prussian blue nanoparticles for synergistic ferroptosis and apoptosis via triggered GPX4 inhibition and concurrent in situ bleomycin toxification