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GSDME-mediated pyroptosis promotes anti-tumor immunity of neoadjuvant chemotherapy in breast cancer

No negative interaction [26]

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Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation

The second factor centers on magnesium , an essential mineral involved in cellular energy production , protein synthesis , and DNA creation