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Tirzepatides imbalanced receptor engagement, which favors GIP receptor activation, combined with biased signaling at the GLP-1 receptor, further enhances insulin secretion and metabolic benefits ( 3.2.2 Regulation of hepatic lipid metabolism Dual GLP-1 receptor agonists facilitate hepatic lipid metabolism through coordinated activation of intracellular signaling pathways that suppress lipogenesis and enhance fatty acid oxidation

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Pharmacokinetics and pharmacodynamics of LC15-0444, a novel dipeptidyl peptidase IV inhibitor, after multiple dosing in healthy volunteers

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Meguro et al., 2024