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Improved gut barrier function reduces systemic inflammation, which supports better metabolic health

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Current management of DKD centres around four key pillars of guideline-directed medical therapy (GDMT): reninangiotensinaldosterone system inhibitors, sodium-glucose cotransporter-2 inhibitors, non-steroidal mineralocorticoid receptor antagonists and glucagon-like peptide-1 receptor agonists

Following the calculation of propensity scores, matching was performed using a greedy nearest-neighbor matching algorithm with a caliper of 0.1 pooled standard deviations