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In the context of GLP-1R agonists, GLP-1-expressing NTS neurons project to the VTA [98], and administration of exendin-4 into this brain region reduces food intake [98,99,100] and the motivation to obtain a food reward [99, 100] without causing aversion [98,99,100]
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Liu J, Shen JX, Wen XF, Guo YX, Zhang GJ
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It may be life-threatening and requires emergency medical treatment
Dose escalation (starting low and increasing slowly) helps reduce side effects, especially nausea
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