red itchy injection site tirzepatide reaction -anyone else? : r/Zepbound Tirzepatide Injection Site Reaction: 6

This is what I mean when I say I take a whole body approach

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Endothelin receptor antagonists prevent endothelin's deleterious effects, being endothelin receptor A (ET A ) the receptor most frequently involved in the negative effects of the endothelin pathway (vasoconstriction, endothelial injury, or podocyte injury) (101)

Theres also a hormonal component to considerespecially in women who are perimenopausal or menopausal, aka a large proportion of patients put on a GLP-1