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Conclusion GLP-1 agonists like semaglutide and dual agonists like tirzepatide represent major breakthroughs in obesity and type 2 diabetes treatment
All are injectable medications that work with the bodys natural appetite and fullness signals, but they are not the same treatment
These beneficial properties do not affect just a single system
Separately, research in adults losing weight through caloric restriction has found that resistance training combined with adequate protein preserves most lean mass
141 This prolonged duration may be driven by albumin binding to the fatty acid residues of GLP-1 RAs and their ability to escape protease metabolism due to amino acid substitutions (Figure 1)
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