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However, patients report severe health conditions related to taking the medication, including stomach paralysis (gastroparesis) and potential pancreatic cancer

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[5] Furthermore, the thermic effect of proteinthe energy required to digest and metabolize itis higher (approximately 20-30%) than other macronutrients, potentially supporting metabolic health during weight loss

This group of laxatives can therefore lead to melanosis coli, an increase in fat in the submucosa, atrophy of "smooth muscle and damage to intrinsic innervation.When there is a predominance of these last two aspects, the function of the large intestine is altered, as discussed elsewhere.The evidence of melanosis coli on a patient must immediately pose the problem on the harmful use of laxatives and symptoms of faecal stasis.In the absence of a history of abuse of anthraquinone laxatives, the finding of melanosis coli it requires further evaluation for the investigation of malignant neoplasm of the large intestine.