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Diabetes Care 34 , 314319 (2011)

To overcome these problems, the multifunctional Pt (IV) prodrugs with excellent stability and superior therapeutic efficacy were developed

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This creates a powerful, dual-action synergistic effect: the L-Carnitine component ensures a steady supply of acetyl-CoA by transporting fats into the mitochondria, while the fumarate component accelerates the Krebs cycle's ability to process that fuel into usable cellular energy

Double knockdown of GPX4 and GPD2 synergistically inhibited tumor growth by exacerbating ferroptosis in vitro and in vivo [86]

Sleep deprivation increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), mimicking the exact hormonal environment that drives post-medication weight regain