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Some GLP-RAs have been shown to penetrate the central nervous system, as confirmed by neuroimaging methods
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The FDA approved once-daily oral semaglutide (Wegovy) at 25 mg on 22 December 2025, making it the first oral GLP-1 approved specifically for chronic weight management in the US
References van Gorkom BA, Karrenbeld A, van Der Sluis T, Koudstaal J, de Vries EG, Kleibeuker JH (2000) Influence of a highly purified senna extract on colonic epithelium
Rev Endocr Metab Disord 21(3):341353 Chavez AM, Carrasco Barria R, Leon-Sanz M (2025) Nutrition support whilst on glucagon-like peptide-1 based therapy
Masui K, Cavenee WK, Mischel PS
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