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Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)
All models were adjusted for the same covariates described above
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In GF mice, the absence of commensal bacteria specifically leads to underdeveloped mucosal lymphoid structures, including Peyers patches and germinal centers, as well as reduced secretory immune factors [35, 39]
Patients consistently report falling asleep faster, staying asleep longer, and waking up feeling genuinely refreshed
Most users experience significant reduction in symptoms after 8-12 weeks as the body adapts to the medication
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