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Before adding insulin, I prefer to maximize incretin therapy (dose optimization or an agent switch) to avoid insulin-associated weight gain

These benefits extend even to non-diabetic individuals, suggesting mechanisms beyond glucose lowering

In December 2025, the CagriSema dossier for weight management was submitted to the US FDA on the basis of the REDEFINE 1 and REDEFINE 2 studies

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It contains the active drug dapagliflozin