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If you accidentally leave your semaglutide at room temperature for longer than the recommended window (usually 28 days after opening), or if it has been exposed to heat above 86F, discard it safely rather than risk reduced effectiveness or potential contamination

"Semaglutide has been extensively examined in robust clinical development programmes and real world evidence studies

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Similarly, in a small 2025 study , researchers found semaglutide (the active ingredient in Ozempic ) was associated with improved total testosterone levels and semen parameters among 25 men with diabetes and obesity

Lower energy during exercise: Reduced calorie intake may affect stamina early on

Metabolism slows, muscle mass may decline, and hormones shift, especially around perimenopause, menopause, or age-related testosterone changes