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Clinicians typically extend each dose step (48 weeks instead of 4) for patients who report persistent nausea, and recommend small, low-fat meals during titration

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Semaglutide cut major cardiovascular events by 20% in people with obesity and existing heart disease but no diabetes, and the benefit showed up early, before most of the weight came off

In rare cases, that could lead to severe health issues like a heart attack, seizure, stroke and even death