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Special considerations : For patients taking tirzepatide (Mounjaro, Zepbound), note that it may reduce the effectiveness of oral contraceptives during initiation and dose escalation

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Lancet 386 , 964973 (2015)

Binding of Androgen- and Estrogen-Like flavonoids to their cognate (Non)Nuclear receptors: a comparison by computational prediction

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For constipation, osmotic or stimulant laxatives may be used when dietary measures are insufficient, whereas loperamide or probiotic supplementation may be considered for persistent diarrhea