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Mainville et al 15 described a 59-year-old woman with refractory HS who showed improvement with a combination of intravenous ertapenem 1 g/d for 6 weeks, minocycline 100 mg/d for 3 months, metformin 500 mg three times daily for 2 months, doxycycline 100 mg/d to bridge to adalimumab (160 mg subcutaneously starting dose then 80 mg subcutaneously), and semaglutide (no dosage listed)

Epub 2011 Nov 26

Rutaecarpine alleviates inflammation and fibrosis by targeting CK2 in diabetic nephropathy

GLP-1 receptor agonists slow gastric emptying, causing food to remain in the stomach longer

GHK-Cu is better tolerated and suited for sensitive skin, but it is not a retinoid replacement by evidence alone