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Real-world data from a 2025 study in Diabetes, Obesity and Metabolism which looked at actual clinical patients rather than trial participants showed tirzepatide patients lost 5.3% of body weight over six months compared to 2.7% with semaglutide
Niu H, Zhou M, Zogona D, Xing Z, Wu T, Chen R, Cui D, Liang F and Xu X (2024)
10.1007/s11892-009-0053-2 48 ShiQ.WangY.HaoQ.VandvikP
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The caloric deficit from the medication plus the increased caloric burn from more intense exercise can continue driving fat loss even as the overall rate slows
Svane MS, Jrgensen NB, Bojsen-Mller KN, Dirksen C, Nielsen S, Kristiansen VB, et al
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