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Despite the widespread use of levothyroxine replacement therapy, a substantial proportion of patients continue to experience persistent symptoms and metabolic dysregulation even after achieving biochemical euthyroidism

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After 36 months, participants experienced: Reduced pain (including pain with touch) Less swelling and discomfort Improved tissue texture Reduction in subcutaneous fat thickness (measured by ultrasound) Interestingly, some women improved even without weight loss , suggesting effects beyond fat reduction

Lys63-linked polyubiquitination may aggravate PD pathology by inhibiting proteasomal degradation of -synuclein (Liu et al., 2002)

"If I feel nauseous, it's working better." Not necessarily