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Although exogenous GIP does not lower glucose in diabetic patients, making it unsuitable for DM2 treatment alone, new GLP-1-GIP co-agonists show promising antidiabetic and weight-reducing effects

For this reason, the effect of Notch inhibition is not selective for L-cells, and the number of K, goblet, and Paneth cells also increases

Months six through nine: peak shedding and early recovery For most patients, shedding peaks around months four through seven and then gradually diminishes

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However, extremes in body size may warrant adjustment