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They represent the point where cardiovascular risk becomes clinically significant

Although recent reviews have described the role of GLP-1 RAs on cardiovascular risk in general, there is a lack of evidence synthesis on local actions of GLP-1 RAs in coronary arteries and the link of these mechanisms to coronary events ((Figure 1)

Monitor heart rates in Saxenda-treated patients and discontinue therapy if sustained increases occur Suicidal behavior and ideation In adult trials, 0.3% of Saxenda-treated patients reported suicidal ideation compared to 0.1% of placebo-treated patients

Patients with significant kidney or liver disease, certain gastrointestinal conditions, or specific medication interactions also need careful assessment

Similarly, dietary approaches that increase NO precursors or mitigate oxidative stress (such as dietary nitrate, CIT/L-arginine, and antioxidant polyphenols) can improve exercise-induced enhancements in endothelial function and microvascular blood flow, thereby augmenting substrate delivery to trained musculature and enhancing training responsiveness in geriatric populations (81)