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The results showed that PMP caused dose and time dependent membrane damage, evidenced by elevated AKP activity, rising from 0.06, 3.1, 11.0 and 6.2 folds at 24 h to 0.07, 9.8, 29.2 and 20.2 folds at 48 h in the PMP1, PMP2, PMP3 and D-cycloserine groups, respectively, compared to the control (Fig
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Formation of the NFT radical anion by cellular reductases To elucidate the mechanism of Nrf2 activation by NFT, we focused on the ability of NFT to yield an activated species capable of oxidizing critical sulfhydryl groups in the Nrf2-Keap1 complex
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It usually begins between the ages of 50 and 70 and is slightly more common in men than women, with a male-to-female ratio of about 1.51 (Chi et al., 2013)
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