Should I consider an SGLT2 inhibitor instead of or in addition to a GLP-1 medication, especially if I have heart failure or kidney disease
Efficacy and safety of liraglutide and semaglutide on weight loss in people with obesity or overweight: a systematic review
Specifically, at normal plasma insulin levels, target tissues fail to initiate a coordinated hypoglycemic response, including suppression of endogenous glucose production, inhibition of lipolysis, promotion of cellular uptake of plasma glucose, and enhancement of net glycogenesis (68)
For many GLP-1 users, that is the likely cause
This option suits individuals who prioritize convenience and wish to avoid injection site rotation
Management includes taking Rybelsus correctly on an empty stomach, eating smaller meals, avoiding trigger foods, and remaining upright after eating