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Patients typically begin with a lower dose, gradually increasing it to the optimal level under medical supervision to minimize side effects and ensure the best results
The activation of GLP-1R using agonists such as exendin-4 has been reported to reduce microglial activation and the production of proinflammatory cytokines (Qian et al., 2022)
J Physiol Pharmacol (2021) 72(3):4617
That makes them uncommon but not rare
This would be consistent with other research on the impact of GLP-1 drugs for obesity on medical budgets: Institute for Clinical and Economic Review (ICER) 2022: Lifetime cost of drugs $274K
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