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It was developed at the University of Arizona by Hruby and Hadley and contains two key modifications from native -MSH: a norleucine substitution at position 4 (replacing methionine) and a D-phenylalanine substitution at position 7 (replacing L-phenylalanine)
Erratum in: Front Endocrinol (Lausanne)
Increased adipose protein carbonylation in human obesity
They work largely by quieting the constant background hunger many people call food noise, slowing how fast the stomach empties, and steadying blood sugar
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