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Hoechst 33342, Annexin V, and PI were also from Thermo Fisher Scientific (Waltham, MA)

Mauras N, Hayes V, Welch S, et al

[1] Important safety considerations include the risk of hypoglycaemia when combined with insulin or sulfonylureas, potential dehydration and acute kidney injury with severe gastrointestinal symptoms, and for semaglutide specifically, possible worsening of diabetic retinopathy in those with pre-existing disease

In general, if a 3% to 4% weight loss has not been achieved after 12 to 16 weeks, long-term treatment is typically stopped

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