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Following subcutaneous administration, tirzepatide reaches peak plasma concentrations (Tmax) in 8 to 72 hours, with steady-state concentrations achieved after approximately 4 weeks of once-weekly dosing

However, the chemical processes behind these processes slightly differ

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The ER chaperone GRP78 (Endoplasmic reticulum chaperone BiP) is used as a marker of ER stress due to its ability to control the activation of transmembrane ER stress sensors Inositol-requiring enzyme 1 (IRE1), Protein kinase RNA-like endoplasmic reticulum kinase (PERK), and Activating transcription factor 6 (ATF6) through a binding-release mechanism 22

A preclinical study conducted by Jauslin et al

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