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Given the screening data indicating that mitochondria are a dominant metabolic target in response to dual SHP2/MEK inhibition across PDAC subtypes, we investigated mitochondrial behavior under MAPK pathway inhibition in more detail

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N Engl J Med 290:13991402 Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC (2015) Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury