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Furthermore, it has been shown that empagliflozin attenuates the decline of cardiac function in mice with HF in the absence of diabetes and that this is associated with reduced priming of NLRP3 inflammasome in the heart (Lee et al., 2017)

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Primary human hepatocytes (PHH) were obtained from BioIVT (donors IAN, IPH, GID) and from Lonza (donors HUM4108, HUM4055B, HUM4229, HUM181501B)