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[6] Methylene Blue also has pharmacological actions on signaling pathways, notably the nitric oxide (NO)-cyclic GMP pathway

While effective in supplementing B12 levels, they are not derived from natural food sources and are formulated to mimic the active forms of B12 found in the body

Vigliante, I., Mannino, G., Maffei, M

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But some studies mention the cases of recurrent miscarriages due to increased IL-12 levels