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For very small doses (0.05 mL or less), a 0.3 mL insulin syringe with finer markings provides better precision than a 1 mL syringe

Furthermore, some evidence suggest that GLP-1 crosses the blood brain barrier to act directly on CNS receptors (Kastin et al., 2002)

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This modulation leads to an enhancement of serotonergic neurotransmission, which is associated with improved mood and reduced anxiety

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however, emerging evidence suggests a potential protective effect