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Given that more than half of total knee and hip arthroplasty patients meet criteria for obesity or morbid obesity, weight loss strategies, particularly pharmacologic approaches like GLP-1 receptor agonists, are becoming increasingly relevant in optimizing surgical outcomes and mitigating complications

( f ) protein expression in lysates from 3D AKP organoids treated 5FU for 72 h, representative of n = 3 biological replicates

Clinical trials have shown positive results regarding the efficacy of AOD-9604 for weight loss in humans, with one study reporting an average loss of 2.6 kg over 12 weeks, compared to 0.8 kg in the placebo group

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