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Med Res Rev 39:404422

By activating the AMPK pathway, they promote glucose uptake and glycogen synthesis in muscle tissue, increase mitochondrial oxidative phosphorylation (OXPHOS) efficiency, reduce lactate production, and achieve "maximum energy utilization"

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This perspective has shifted substantially over the past 2 decades as accumulating evidence has demonstrated that both tissues secrete bioactive peptides that function as hormones, influencing glucose metabolism, energy expenditure, reproductive physiology, and aspects of aging

& Verardo, V

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