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In markets where there is state/PMI reimbursement of GLP-1 treatment for obesity (eg the US), retatrutide is likely to be reserved as a second-line GLP-1 for those who have failed to lose sufficient weight with a cheaper alternative (such as semaglutide or tirzepatide)
Many patients find that staying hydrated, eating protein-rich meals, and maintaining consistent meal timing help manage hunger during this window
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