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In situ hybridization (ISH) for Stella showed a complete absence of PGCs in E12.5 Trim37 cko embryos (Fig

Given its intimate association with ROS, cell death can be triggered by genetically programmed mechanisms (such as apoptosis, necrosis, and pyroptosis), metabolic dysfunction, including ferroptosis, cuproptosis, oxytosis, disulfidptosis [6] and the recently identified sodium-dependent cell death [7]

Neuroprotection in the Central Nervous System Glutathione (GSH) plays a vital neuroprotective role in the central nervous system (CNS), primarily by regulating redox homeostasis, detoxifying electrophilic compounds, and modulating excitotoxic signaling pathways

Acta 1658, 181186

Practitioners are encouraged to stay updated with ongoing research and contribute to studies that explore these biochemical pathways